New Biological Markers of Bone Metabolism in Osteoporosis Treatment
نویسندگان
چکیده
منابع مشابه
New Biological Markers of Bone Metabolism in Osteoporosis Treatment
Osteoporosis is a chronic skeletal disorder characterized by low bone mass and poor bone quality. It is a major public health concern in aging society and requires life-long treatment for preventing fragility bone fracture. One of the main limitations in treatment of osteoporosis is the lack of smart surrogate markers that reflect the status of bone quality and measure the effect of a specific ...
متن کامل[Biochemical bone markers and biological effects of osteoporosis therapy].
Osteoporoza je poreme aj skeleta u ijoj osnovi se nalazi poreme aj koštane vrstine koji vodi pove anju rizika od fraktura. Koštana snaga, odnosno vrstina, integriše koštani kvantitet (mineralna gustina, pre nik kosti, debljina korteksa) i kvalitet (mikroarhitektonika, koštani promet) . Više od 1,5 miliona vertebralnih i nevertebralnih fraktura javlja se na bazi osteoporoze od koje u svetu boluj...
متن کاملNew automated multiplex assay for bone turnover markers in osteoporosis.
BACKGROUND Serum C-terminal cross-linked telopeptide of type I collagen (CTX-I), N-terminal propeptide of type I collagen (PINP), and osteocalcin (OC) are among the most sensitive bone turnover markers for evaluating osteoporosis. Each marker is currently measured individually by manual or automated immunoassays that are time consuming and require substantial sample volume. We evaluated the per...
متن کاملAssessment of urinary bone markers for monitoring treatment of osteoporosis.
BACKGROUND The usefulness of urinary markers of bone turnover in monitoring therapy depends on their within-person variability compared with their responses to therapy. The aim of this study was to assess the performance of two such markers on this basis. METHODS We measured variation, during a whole year, of cross-linked N-terminal telopeptide of collagen I (NTx) and urinary deoxypyridinolin...
متن کاملBone markers and osteoporosis therapy.
Several factors are involved in determining bone quality including bone density, bone turnover, the extent of trabecular bone connectivity, cortical porosity and geometry. Metabolically active and in a continuous process of remodeling, approximately 20% of bone tissue is renewed annually. Bone turn over markers (BTM) are frequently used in clinical trials and to provide valid information about ...
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ژورنال
عنوان ژورنال: Endocrinology and Metabolism
سال: 2016
ISSN: 2093-596X,2093-5978
DOI: 10.3803/enm.2016.31.3.400